deepundergroundpoetry.com
Gila Monster Diabetes Cure
Mr Gila waddles his way
around the American Southwest
all one or two pounds of himself
he moves pretty slow
if you get too close
he does a very rapid bite
He wears brightly coloured scales
not trying to blend in
or hide from predators
His nose sniffs out bird eggs
from far up in a nest on top
of a cactus
and desert tortoise eggs
buried six inches deep.
A pretty tame diet
for a lizard
With venomous fangs.
He may eat just two times during a year
Storing his meals by fattening up
his hefty tail.
Eating once in the spring
his body then lives off
a slow trickle of the fat released
that was stored in his tail.
until he eats again in the fall
His body adds a hormone
into the stored fat
It gets released with the fat,
sending it floating through
the bloodstream
that bathes the brain,
that has receptors
that the hormone fits into,
that sends a feeling
Into his brain that says,
"I'm satisfied"
this hormone also awakens his
pancreas to keep blood sugar levels controlled. The pancreas also has receptors, like the brain, allowing the hormone to activate it into action.
Humans have a version that is released by special cells in our intestnes, as digested food passes thru the intestines, then into the blood stream.
So, this hormone is
floating around the bloodstream
in microgram amounts, yes,
but will it just get blown away
like an outdoor smoker after he puts out his cigar?
or will this hormone
stay in the bloodstream.
like smelling the cigar smoke in a room
with closed windows?
Well,
there is an enzyme, which breaks down the hormone, like a scrubber, constantly removing the hormone.
So the "Satisfaction" hormone actually only has a few minutes of life to be a signal to our brain and pancreas.
Once the food is gone,
the intestines stop emitting the hormone
and in a few minutes, the blood has been
scrubbed clean of it,
Our brain senses that the food flow has
stopped: The hormone signal is gone.
The pancreas also knows the incoming flood of food is over with, so it can rest and recuperate.
Without the hormone,
the pancreas goes dormant.
In the type two diabetic,
the intestines do not produce enough of the satisfaction hormone,
so thet tend to keep eating and eating.
Also, without the hormone, the pancreas remains dormant, and does not wake up to control sugar levels, from the food flooding in from the intestines.
Well, I have really laid a lot on you, the reader.
Now,
Mr. Gila makes a painful venom.
Not to hunt with,
but to educate.
Venom coming from
a hole in his lower tooth
he bites an attacker
then will flip
upside down
so his poison will drain
into the bite
a bite which he takes
his own sweet time to release you from.
if you are unfortunate to recieve a bite from this slow moving waddling lizard
it may be that you are a hungry coyote on the prowl, who invaded Mr.Gila's personal space
in order to eat him for a meal.
for the next few days it will be all you can do to just lie in agony,
giving you lots of time to think about ever getting too close to Mr. Gila again.
At least you will not feel hungry,
you see, Mr. Gila's venom
includes a dose of his very own
meal satisfaction hormone.
Mr. Gila hopes you will lose interest in trying to eat him if you don't feel hungry anymore.
through evolution,
Mr. Gila has borrowed the satisfaction hormone
and added it to it's bite(venom)
because of its borrowed nature, the satisfaction hormone still comes with its additional ability of being able to wake up the pancreas to control blood sugar levels.
After your days of pure pain wear off,
Mr. Gila's venom is not like snake venom, which wants you paralyzed so it can swallow you.
Mr. Gila Monster wants you alive, to hold on your (and his) territory.
If you died from his bite,
soon another hapless coyote would come along, and get
bitten all over again.
No he wants you as a lifelong neighbor, eating your various diet of mice and rabbits at hand,
because you who have learned to
never
ever
mess with mr. Gila again.
unless you are a scientist
who explores nature
for the sake of knowledge
and understanding
who uses her art to collect
Mr. gila's venom
to study it,
to separate it
into its varied parts
Who knows what could be there?
An easy way to out
is to inject
the separated parts
of the venom
into lab rats.
And sit back,
to warch what happens
if anything
to the rats
Discovering one rat writhes in agony
While another quits over-eating,
loses the fat, and has his diabetes clear
She realizes this component of Mr. Gila's venom might help humans with type two diabetes.
Mr. Gila's lizard digestive system,
is similar enough to the human system,
since it works on most of the creatures
it bites, it attests to how close all animals are, chemically, to each other.
Close, but not exact.
If the Gila"s satisfaction hormone was actually identical to the human version
it would get scrubbed away in just a few minutes.
The gila monster's satisfaction hormone has evolved to not be susceptible to getting scrubbed apart.
It lasts a good several hours in the animal it bites
enough time to quell the hunger pangs of the attacker, helping Mr.Gila make an escape.
The force of evolution happened,
as random mutations happen in
the structure of the satisfaction hormone.
one that would be more resistant to being scrubbed away,
would take away the hunger feelings
of the attacking animal that got bit
for a longer period of time,
giving that Gila monster a survival advantage,
going on to have more baby gilas
that would also carry the new longer acting venom.
After millions of years of the evolutionary
dance of 'Survival of the fittest'
the Gila monster's satisfaction hormone has evolved to last for several hours inside the creature it has bitten.
It also makes it last for hours on end, inside of a diabetic, so just a few micrograms can take away hunger,
plus keep the pancreas active, for seversl
hours.
And so was discovered 'Exenatide', in 1992,
The 'hunger-satisfaction' component
of gila monster venom, millions of years in the evolutionary slow cooker available as an FDA approved injection taken before a meal,
then in 2012, it was encapsulated in slow release microspheres, so 2 milligrams of gila monster venom could keep a diabetic
feeling food-satisfiedas well as keeping their pancreas controlling blood glucose, for a whole week on one 2 mg injection.
pat youself on the back
you just made it through
another educational quest.
around the American Southwest
all one or two pounds of himself
he moves pretty slow
if you get too close
he does a very rapid bite
He wears brightly coloured scales
not trying to blend in
or hide from predators
His nose sniffs out bird eggs
from far up in a nest on top
of a cactus
and desert tortoise eggs
buried six inches deep.
A pretty tame diet
for a lizard
With venomous fangs.
He may eat just two times during a year
Storing his meals by fattening up
his hefty tail.
Eating once in the spring
his body then lives off
a slow trickle of the fat released
that was stored in his tail.
until he eats again in the fall
His body adds a hormone
into the stored fat
It gets released with the fat,
sending it floating through
the bloodstream
that bathes the brain,
that has receptors
that the hormone fits into,
that sends a feeling
Into his brain that says,
"I'm satisfied"
this hormone also awakens his
pancreas to keep blood sugar levels controlled. The pancreas also has receptors, like the brain, allowing the hormone to activate it into action.
Humans have a version that is released by special cells in our intestnes, as digested food passes thru the intestines, then into the blood stream.
So, this hormone is
floating around the bloodstream
in microgram amounts, yes,
but will it just get blown away
like an outdoor smoker after he puts out his cigar?
or will this hormone
stay in the bloodstream.
like smelling the cigar smoke in a room
with closed windows?
Well,
there is an enzyme, which breaks down the hormone, like a scrubber, constantly removing the hormone.
So the "Satisfaction" hormone actually only has a few minutes of life to be a signal to our brain and pancreas.
Once the food is gone,
the intestines stop emitting the hormone
and in a few minutes, the blood has been
scrubbed clean of it,
Our brain senses that the food flow has
stopped: The hormone signal is gone.
The pancreas also knows the incoming flood of food is over with, so it can rest and recuperate.
Without the hormone,
the pancreas goes dormant.
In the type two diabetic,
the intestines do not produce enough of the satisfaction hormone,
so thet tend to keep eating and eating.
Also, without the hormone, the pancreas remains dormant, and does not wake up to control sugar levels, from the food flooding in from the intestines.
Well, I have really laid a lot on you, the reader.
Now,
Mr. Gila makes a painful venom.
Not to hunt with,
but to educate.
Venom coming from
a hole in his lower tooth
he bites an attacker
then will flip
upside down
so his poison will drain
into the bite
a bite which he takes
his own sweet time to release you from.
if you are unfortunate to recieve a bite from this slow moving waddling lizard
it may be that you are a hungry coyote on the prowl, who invaded Mr.Gila's personal space
in order to eat him for a meal.
for the next few days it will be all you can do to just lie in agony,
giving you lots of time to think about ever getting too close to Mr. Gila again.
At least you will not feel hungry,
you see, Mr. Gila's venom
includes a dose of his very own
meal satisfaction hormone.
Mr. Gila hopes you will lose interest in trying to eat him if you don't feel hungry anymore.
through evolution,
Mr. Gila has borrowed the satisfaction hormone
and added it to it's bite(venom)
because of its borrowed nature, the satisfaction hormone still comes with its additional ability of being able to wake up the pancreas to control blood sugar levels.
After your days of pure pain wear off,
Mr. Gila's venom is not like snake venom, which wants you paralyzed so it can swallow you.
Mr. Gila Monster wants you alive, to hold on your (and his) territory.
If you died from his bite,
soon another hapless coyote would come along, and get
bitten all over again.
No he wants you as a lifelong neighbor, eating your various diet of mice and rabbits at hand,
because you who have learned to
never
ever
mess with mr. Gila again.
unless you are a scientist
who explores nature
for the sake of knowledge
and understanding
who uses her art to collect
Mr. gila's venom
to study it,
to separate it
into its varied parts
Who knows what could be there?
An easy way to out
is to inject
the separated parts
of the venom
into lab rats.
And sit back,
to warch what happens
if anything
to the rats
Discovering one rat writhes in agony
While another quits over-eating,
loses the fat, and has his diabetes clear
She realizes this component of Mr. Gila's venom might help humans with type two diabetes.
Mr. Gila's lizard digestive system,
is similar enough to the human system,
since it works on most of the creatures
it bites, it attests to how close all animals are, chemically, to each other.
Close, but not exact.
If the Gila"s satisfaction hormone was actually identical to the human version
it would get scrubbed away in just a few minutes.
The gila monster's satisfaction hormone has evolved to not be susceptible to getting scrubbed apart.
It lasts a good several hours in the animal it bites
enough time to quell the hunger pangs of the attacker, helping Mr.Gila make an escape.
The force of evolution happened,
as random mutations happen in
the structure of the satisfaction hormone.
one that would be more resistant to being scrubbed away,
would take away the hunger feelings
of the attacking animal that got bit
for a longer period of time,
giving that Gila monster a survival advantage,
going on to have more baby gilas
that would also carry the new longer acting venom.
After millions of years of the evolutionary
dance of 'Survival of the fittest'
the Gila monster's satisfaction hormone has evolved to last for several hours inside the creature it has bitten.
It also makes it last for hours on end, inside of a diabetic, so just a few micrograms can take away hunger,
plus keep the pancreas active, for seversl
hours.
And so was discovered 'Exenatide', in 1992,
The 'hunger-satisfaction' component
of gila monster venom, millions of years in the evolutionary slow cooker available as an FDA approved injection taken before a meal,
then in 2012, it was encapsulated in slow release microspheres, so 2 milligrams of gila monster venom could keep a diabetic
feeling food-satisfiedas well as keeping their pancreas controlling blood glucose, for a whole week on one 2 mg injection.
pat youself on the back
you just made it through
another educational quest.
Published 26th Dec 2016
| Edited 31st Dec 2016
All writing remains the property of the author. Don't use it for any purpose without their permission.
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26th Dec 2016 7:49pm
27th Dec 2016 5:33am
